Excreted Unchanged %
None
Half-Life (Normalesrd) Hours
0.3-2/Unchanged
Plasma Protein Binding %
>90
Volume Of Distribution L/Kg
0.06-0.1
Dose For Normal Renal Function
75 U/kg load, then 0.5 U/kg/min
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [A]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Kandrotas RJ. Heparin pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 1992; 22: 359-74. [PMID: 1505142] / Perry PJ, Herron GR, King JC. Heparin half-life in normal and impaired renal function. Clin Pharmacol Ther. 1974; 16: 514-9. [PMID: 4413659] / Teien AN, Bjoornson J. Heparin elimination in uraemic patients on Haemodialysis. Scand J Haematol. 1976; 17: 29-35. [PMID: 959771]
Toxicity Notes
May add to bleeding tendency in CKD 4-5. Half-life increases with dose.