Half-Life (Normalesrd) Hours
2.5-5/4.7-18.5
Plasma Protein Binding %
<10
Volume Of Distribution L/Kg
0.2
Dose For Normal Renal Function
10 mg (by inhalation) q12h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No dose adjustment, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: No dose adjustment, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [B]
References
Cass LM, Efthymiopoulos C, Marsh J, Bye A. Effect of renal impairment on the pharmacokinetics of intravenous zanamivir. Clin Pharmacokinet. 1999; 36 Suppl 1: 13-9. [PMID: 10429836]
Toxicity Notes
Bioavailability from inhalation and systemic exposure to drug is low.