Excreted Unchanged %
70-80
Half-Life (Normalesrd) Hours
8-12
Plasma Protein Binding %
7
Volume Of Distribution L/Kg
1.2-1.3
Dose For Normal Renal Function
300 mg q24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
Avoid [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [B]
References
Izzedine H, Launay-Vacher V, Jullien V, Aymard G, Duvivier C, Deray G. Pharmaco-kinetics of tenofovir in haemodialysis. Nephrol Dial Transplant. 2003; 18: 1931-3. [PMID: 12937248]
Toxicity Notes
Acute renal failure and Fanconi syndrome reported. Drug is administered as prodrug tenofovir disoproxil fumarate. No information available on dosing in subjects with reduced GFR or on dialysis. Manufacturer recommends avoiding use when CrCl <60 mL/min.