Stavudine

Excreted Unchanged %
35-40
Half-Life (Normalesrd) Hours
1.0-1.4/5.5-8.0
Plasma Protein Binding %
<1
Volume Of Distribution L/Kg
0.5
Dose For Normal Renal Function
40 mg (>60 kg) q12h
Second Dose
Second Dose: 30 mg (<60 kg) q12h
Adjustment For Renal Failure Method
D, I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50% q12-24h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% q24h [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for GFR <10 (after dialysis)
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [B]
References
Dudley MN, Graham KK, Kaul S, Geletko S, Dunkle L, Browne M, et al. Pharmacokinetics of stavudine in patients with AIDS or AIDS-related complex. J Infect Dis. 1992; 166: 480-5. [PMID: 1323615] / Grasela DM, Stoltz RR, Barry M, Bone M, Mangold B, O&#146; Grady P, et al. Pharmacokinetics of single-dose oral stavudine in subjects with renal impairment and in subjects requiring hemodialysis. Antimicrob Agents Chemother. 2000; 44: 2149-53.[PMID: 10898689] / Horton CM, Dudley MN, Kaul S, Mayer KH, Squires K, Dunkle L, et al. Population pharmacokinetics of stavudine (d4T) in patients with AIDS or advanced AIDS-related complex. Antimicrob Agents Chemother. 1995; 39: 2309-15. [PMID: 8619587]