Excreted Unchanged %
10-40
Half-Life (Normalesrd) Hours
30-60/No data
Plasma Protein Binding %
0
Volume Of Distribution L/Kg
9-15
Dose For Normal Renal Function
1000-1200 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
Avoid [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Avoid
Supplement For Dialysis [Recommendation Level]: Pd
PD: Avoid
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [B]
References
Aebi C, Headrick CL, McCracken GH, Lindsay CA. Intravenous ribavirin therapy in a neonate with disseminated adenovirus infection undergoing extracorporeal membrane oxygenation: pharmacokinetics and clearance by hemofiltration. J Pediatr. 1997; 130: 612-5. [PMID: 9108860] / Kramer TH, Gaar GG, Ray CG, Minnich L, Copeland JG, Connor JD. Hemodialysis clearance of intravenously administered ribavirin. Antimicrob Agents Chemother. 1990; 34: 489-90. [PMID: 2334164] / Laskin OL, Longstreth JA, Hart CC, Scavuzzo D, Kalman CM, Connor JD, et al. Ribavirin disposition in high-risk patients for acquired immunodeficiency syndrome. Clin Pharmacol Ther. 1987; 41: 546-55. [PMID: 3568539] / Lertora JJ, Rege AB, Lacour JT, Ferencz N, George WJ, VanDyke RB, et al. Pharmacokinetics and long-term tolerance to ribavirin in asymptomatic patients infected with human immunodeficiency virus. Clin Pharmacol Ther. 1991; 50: 442-9. [PMID: 1680594] / Paroni R, Del Puppo M, Borghi C, Sirtori CR, Galli Kienle M. Pharmacokinetics of ribavirin and urinary excretion of the major metabolite 1,2,4-triazole-3-carboxamide in normal volunteers. Int J Clin Pharmacol Ther Toxicol. 1989; 27: 302-7. [PMID: 2737800] / Roberts RB, Laskin OL, Laurence J, Scavuzzo D, Murray HW, Kim YT, et al. Ribavirin pharmacodynamics in high-risk patients for acquired immunodeficiency syndrome. Clin Pharmacol Ther. 1987; 42: 365-73. [PMID: 2444379]
Toxicity Notes
Half-life data from multiple doses. Loading dose required. Oral absorption 40%. Contraindicated for GFR <50 mL/min.