Half-Life (Normalesrd) Hours
23/23
Plasma Protein Binding %
50-60
Volume Of Distribution L/Kg
1.2-1.4
Dose For Normal Renal Function
200 mg qd 14 d, then q12h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: No adjustment necessary, [B]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [B]
References
Cheeseman SH, Hattox SE, McLaughlin MM, Koup RA, Andrews C, Bova CA, et al. Pharmacokinetics of nevirapine: initial single-rising-dose study in humans. Antimicrob Agents Chemother. 1993; 37: 178-82. [PMID: 8452345] / Havlir D, Cheeseman SH, McLaughlin M, Murphy R, Erice A, Spector SA, et al. High-dose nevirapine: safety, pharmacokinetics, and antiviral effect in patients with human immunodeficiency virus infection. J Infect Dis. 1995; 171: 537-45. [PMID: 7533197] / Izzedine H, Launay-Vacher V, Aymard G, Legrand M, Deray G. Pharmacokinetic of nevirapine in haemodialysis [Letter]. Nephrol Dial Transplant. 2001; 16: 192-3. [PMID: 11209031] / Izzedine H, Launay-Vacher V, Deray G. Pharmacokinetics of ritonavir and nevirapine in peritoneal dialysis [Letter]. Nephrol Dial Transplant. 2001; 16: 643. [PMID: 11239054]
Toxicity Notes
May be partially cleared by hemodialysis and peritoneal dialysis. Half-life is about 45 hours initially, then declines to about 23 hours after 2-4 weeks. Extraction ratio for HD about 45%