Half-Life (Normalesrd) Hours
3.5-5.5/No data
Plasma Protein Binding %
>98
Volume Of Distribution L/Kg
2-7
Dose For Normal Renal Function
750 mg q8h
Second Dose
Second Dose: 1250 mg bid
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [C]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [D]
References
Paci-Bonaventure S, Hafi A, Vincent I, Quertainmont Y, Goujard C, Charpentier B,et al. Lack of removal of nelfinavir during a haemodialysis session in an HIV-1infected patient with hepatic and renal insufficiency [Letter]. Nephrol Dial Transplant. 2001; 16: 642-3. [PMID: 11239052]