Half-Life (Normalesrd) Hours
4-6/12-17
Plasma Protein Binding %
98-99
Volume Of Distribution L/Kg
0.5
Dose For Normal Renal Function
400 mg q12h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
400 mg q12h [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
400 mg q12h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
400 mg q12h [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No dose adjustment, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [D]
References
Izzedine H, Launay-Vacher V, Legrand M, Lieberherr D, Caumes E, Deray G. ABT 378/r: a novel inhibitor of HIV-1 protease in haemodialysis [Letter]. AIDS. 2001; 15: 662-4. [PMID: 11317012]
Toxicity Notes
Multiple drug interactions. No data in renal insufficiency; single patient studied on HD.