Dose For Normal Renal Function
1 tablet bid
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
Avoid [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Use each agent independently per manufacturer
Toxicity Notes
Tablet contains 150 mg lamivudine and 300 mg zidovudine. Use in renal failure (CrCl <50 mL/min) not recommended. For CrCl <50 mL/min, use each drug individually with appropriate dose adjustment. See individual drugs for pharmokinetic data. No pharmokinetic interaction between lamivudine and zidovudine in combination.