Dose For Normal Renal Function
1000 mg q8h
Adjustment For Renal Failure Method
D, I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
1500 mg q24h [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
500-1000 mg q24h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
500 mg q48-96h [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 500 mg 3 weekly post hd, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, recommend IV form
References
Anderson RD, Griffy KG, Jung D, Dorr A, Hulse JD, Smith RB. Ganciclovir absolute bioavailability and steady-state pharmacokinetics after oral administration of two 3000-mg/d dosing regimens in human immunodeficiency virus- and cytomegalovirus-seropositive patients. Clin Ther. 1995; 17: 425-32. [PMID: 7585846]