Half-Life (Normalesrd) Hours
8/No data
Plasma Protein Binding %
90
Volume Of Distribution L/Kg
8.2
Dose For Normal Renal Function
700-1400 mg q12h
Second Dose
Second Dose: 1400 mg q24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
No data: 100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
No data: 100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
No data: 100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicable
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [D]
Toxicity Notes
Dose is 1400 mg q12h without ritonavir (q.v.); with ritonavir the dose can be 700 mg q12h or 1400 mg qd.