Excreted Unchanged %
50-65
Half-Life (Normalesrd) Hours
1.6-2.9/10-22
Plasma Protein Binding %
<25
Volume Of Distribution L/Kg
1.5
Dose For Normal Renal Function
500 mg q8h for herpes zoster; 125 mg q12h for genital herpes
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q12-24h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% q24h [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, recommend IV ganciclovir
References
Boike SC, Pue MA, Freed MI, Audet PR, Fairless A, Ilson BE, et al. Pharmacokinetics of famciclovir in subjects with varying degrees of renal impairment. Clin Pharmacol Ther. 1994; 55: 418-26. [PMID: 8162668] / Pue MA, Benet LZ. Pharmacokinetcs of famciclovir in man. Antiviral Chem Chemother. 1993; 4(Suppl 1): 47-55. [PMID unavailable]
Toxicity Notes
Metabolized to active compound penciclovir.