Half-Life (Normalesrd) Hours
40-75/No data
Plasma Protein Binding %
99
Volume Of Distribution L/Kg
4
Dose For Normal Renal Function
600 mg daily
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No dose adjustment, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: No dose adjustment, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Gill MJ, Ostrop NJ, Fiske WD, Brennan JM. Efavirenz dosing in patients receiving continuous ambulatory peritoneal dialysis [Letter]. AIDS. 2000; 14: 1062-4.[PMID: 10853991] / Izzedine H, Aymard G, Launay-Vacher V, Hamani A, Deray G. Pharmacokinetics of efavirenz in a patient on maintenance haemodialysis [Letter]. AIDS. 2000; 14: 618-9. [PMID: 10780727]
Toxicity Notes
Multiple drug interactions.