Half-Life (Normalesrd) Hours
12/500
Plasma Protein Binding %
60
Volume Of Distribution L/Kg
3-8
Dose For Normal Renal Function
100 mg q12h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q12h [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q24-48h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q7d[D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Horadam VW, Sharp JG, Smilack JD, McAnalley BH, Garriott JC, Stephens MK, et al. Pharmacokinetics of amantadine hydrochloride in subjects with normal and impaired renal function. Ann Intern Med. 1981; 94: 454-8. [PMID: 7212501] / Wu MJ, Ing TS, Soung LS, Daugirdas JT, Hano JE, Gandhi VC. Amantadine hydrochloride pharmacokinetics in patients with impaired renal function. Clin Nephrol. 1982; 17: 19-23. [PMID: 7035042]