Half-Life (Normalesrd) Hours
7/15
Plasma Protein Binding %
<5
Volume Of Distribution L/Kg
0.4
Dose For Normal Renal Function
10 mg q24h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
10 mg q48h (q72h for <20 mL/min) [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
10 mg q72h[B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 10 mg weekly after dialysis, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: [B]
References
Fontaine H, Vallet-Pichard A, Chaix ML, Currie G, Serpaggi J, Verkarre V, et al. Efficacy and safety of adefovir dipivoxil in kidney recipients, hemodialysis patients, and patients with renal insufficiency. Transplantation. 2005; 80: 1086-92. [PMID: 16278590]
Toxicity Notes
Nephrotoxic in higher IV doses; risk lower with recommended oral doses. Administered as adefovir dipivoxil, converted to adefovir. HD (4 hr) removes about 35% of dose with an extraction efficiency of 63%.