Half-Life (Normalesrd) Hours
1.5/2
Plasma Protein Binding %
50
Volume Of Distribution L/Kg
0.86
Dose For Normal Renal Function
300 mg q12h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
No change [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
No change [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
No change [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100% dose, [D]
References
Izzedine H, Launay-Vacher V, Aymard G, Legrand M, Deray G. Pharmacokinetics of abacavir in HIV-1-infected patients with impaired renal function. Nephron. 2001; 89: 62-7. [PMID: 11528234]