Quinine

Excreted Unchanged %
5-20
Half-Life (Normalesrd) Hours
3-20/Unchanged
Plasma Protein Binding %
70
Volume Of Distribution L/Kg
0.7-3.7
Dose For Normal Renal Function
650 mg q8h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q8h[A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q8-12h[A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q24h[A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [B]
References
Davies JG, Greenwood EF, Kingswood JC, Sharpstone P, Street MK. Quinine clearance in continuous venovenous hemofiltration. Ann Pharmacother. 1996; 30: 487-90. [PMID: 8740330] / Davies DT, Bicknell RJ. The effect of testosterone on the responsiveness of the quail&#146; s pituitary to luteinizing hormone-releasing hormone (LH-RH) during photoperiodically induced testicular growth. Gen Comp Endocrinol. 1976; 30: 487-99. [PMID: 795712] / Krishna S, White NJ. Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications. Clin Pharmacokinet. 1996; 30: 263-99. [PMID: 8983859] / Rimchala P, Karbwang J, Sukontason K, Banmairuroi V, Molunto P, Na-Bangchang K. Pharmacokinetics of quinine in patients with chronic renal failure. Eur J Clin Pharmacol. 1996; 49: 497-501. [PMID: 8706776]
Toxicity Notes
In severe malaria cases do not reduce dose/interval.