Excreted Unchanged %
15-30
Half-Life (Normalesrd) Hours
80-100/Unchanged
Plasma Protein Binding %
27
Volume Of Distribution L/Kg
2.9
Dose For Normal Renal Function
50-75 mg q24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100%[D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100%[D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 30-50, [D]
Toxicity Notes
Doses are for treatment of toxoplasmosis. Antimalarial doses are much lower. Reduces renal secretion of creatinine.