Half-Life (Normalesrd) Hours
4-7/No data
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
3-4
Dose For Normal Renal Function
15 mg (base) q24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
No data: 100%[D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
No data: 100%[D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
No data: 100%[D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 30-50, [D]
References
Greaves J, Evans DA, Gilles HM, Fletcher KA, Bunnag D, Harinasuta T. Plasma kinetics and urinary excretion of primaquine in man. Br J Clin Pharmacol. 1980; 10: 399-404. [PMID: 6934796] / Mihaly GW, Ward SA, Edwards G, Orme ML, Breckenridge AM. Pharmacokinetics of primaquine in man: identification of the carboxylic acid derivative as a major plasma metabolite. Br J Clin Pharmacol. 1984; 17: 441-6. [PMID: 6721990]
Toxicity Notes
Methemoglobinemia at high doses. Intravascular hemolysis in patients with G6PD deficiency.