Half-Life (Normalesrd) Hours
2.8-12/73-118
Plasma Protein Binding %
69
Volume Of Distribution L/Kg
3-4
Dose For Normal Renal Function
4.0 mg/kg q24h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q24h[A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q24h[A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q24-36h[A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for GFR <10; 0.75 g after each HD
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 30-50, [D]
References
Conte JE Jr. Pharmacokinetics of intravenous pentamidine in patients with normal renal function or receiving hemodialysis. J Infect Dis. 1991; 163: 169-75. [PMID: 1984463] / Conte JE Jr, Upton RA, Lin ET. Pentamidine pharmacokinetics in patients with AIDS with impaired renal function. J Infect Dis. 1987; 156: 885-90. [PMID: 3680992]
Toxicity Notes
Nephrotoxic.