Half-Life (Normalesrd) Hours
15-33 days/No data
Plasma Protein Binding %
98
Volume Of Distribution L/Kg
20
Dose For Normal Renal Function
1250 mg (for treatment; see notes) in two doses
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
No data: 100%[D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
No data: 100%[D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Crevoisier CA, Joseph I, Fischer M, Graf H. Influence of hemodialysis on plasma concentration-time profiles of mefloquine in two patients with end-stage renal disease: a prophylactic drug monitoring study. Antimicrob Agents Chemother. 1995; 39: 1892-5. [PMID: 7486943]
Toxicity Notes
Treatment: 750 mg initially, then 500 mg 12 hr later. Prophylaxis: 250 mg 1 week before travel until 4 weeks after travel.