Half-Life (Normalesrd) Hours
7-14 days/5-50 days
Plasma Protein Binding %
50-65
Volume Of Distribution L/Kg
>100
Dose For Normal Renal Function
2.5 g (for treatment; see notes) over 3 days
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100%[D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50%[D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Gustafsson LL, Walker O, Alvá n G, Beermann B, Estevez F, Gleisner L, et al. Dis-position of chloroquine in man after single intravenous and oral doses. Br J Clin Pharmacol. 1983; 15: 471-9. [PMID: 6849784]
Toxicity Notes
Treatment: 1 g initially, then 0.5 g in 6 hr, then 0.5 g daily for 2 days. Prophylaxis: 500 mg weekly starting 1-2 weeks before travel and ending 4 weeks after travel.