Excreted Unchanged %
15-30
Half-Life (Normalesrd) Hours
1.5-5.0/1.8-11.0
Plasma Protein Binding %
60-90
Volume Of Distribution L/Kg
0.9
Dose For Normal Renal Function
600 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50-100%[D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50-100%[D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 30-50
References
Acocella G. Clinical pharmacokinetics of rifampicin. Clin Pharmacokinet. 1978; 3: 108-27. [PMID: 346286] / Kenny MT, Strates B. Metabolism and pharmacokinetics of the antibiotic rifampin. Drug Metab Rev. 1981; 12: 159-218. [PMID: 7028436]
Toxicity Notes
Many drug interactions.