Excreted Unchanged %
5-10
Half-Life (Normalesrd) Hours
16-69/Unchanged
Plasma Protein Binding %
71-89
Volume Of Distribution L/Kg
8.2-9.3
Dose For Normal Renal Function
300 mg q24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100%[A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100%[A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [B]
References
Bassilios N, Launay-Vacher V, Hamani AA, Masias L, Peytavin G, Fau JB, et al. Pharmacokinetics and dosage adjustment of rifabutin in a haemodialysis patient [Letter]. Nephrol Dial Transplant. 2002; 17: 531-2. [PMID: 11865118] / Narang PK, Schoenfelder J, Bianchine JR. Impact of altered rifabutin disposition in renal disease on its safety in AIDS patients. AIDS. 1992; 6(Suppl 1): 90. [PMID unavailable] / Skinner MH, Hsieh M, Torseth J, Pauloin D, Bhatia G, Harkonen S, et al. Pharmacokinetics of rifabutin. Antimicrob Agents Chemother. 1989; 33: 1237-41. [PMID: 2552902]