Half-Life (Normalesrd) Hours
9/26
Plasma Protein Binding %
5
Volume Of Distribution L/Kg
0.75-1.3
Dose For Normal Renal Function
15-30 mg/kg (up to 2.5 g) q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100%[A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50-100%[A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 40 mg/kg 24 hr before each 3/wk dialysis, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: 100%, [B]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Lacroix C, Hermelin A, Guiberteau R, Guyonnaud C, Nouveau J, Duwoos H, et al. Haemodialysis of pyrazinamide in uraemic patients. Eur J Clin Pharmacol. 1989; 37: 309-11. [PMID: 2612545] / Stamatakis G, Montes C, Trouvin JH, Farinotti R, Fessi H, Kenouch S, et al. Pyrazinamide and pyrazinoic acid pharmacokinetics in patients with chronic renal failure. Clin Nephrol. 1988; 30: 230-4. [PMID: 3214968] / Woo J, Leung A, Chan K, Lai KN, Teoh R. Pyrazinamide and rifampicin regimens for patients on maintenance dialysis. Int J Artif Organs. 1988; 11: 181-5. [PMID: 3403055]
Toxicity Notes
Impairs urate excretion. Can precipitate gout. Alternative dose of 25-30 mg/kg after each thrice weekly hemodialysis treatment has been suggested.