Excreted Unchanged %
5-30
Half-Life (Normalesrd) Hours
0.7-4/1-17
Plasma Protein Binding %
4-30
Volume Of Distribution L/Kg
0.75
Dose For Normal Renal Function
300 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100%[A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100%[A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 30-50, [D]
References
Gold CH, Buchanan N, Tringham V, Viljoen M, Strickwold B, Moodley GP. Isoniazid pharmacokinetics in patients in chronic renal failure. Clin Nephrol. 1976; 6: 365-9. [PMID: 954244]
Toxicity Notes
Supplement with 50-100 mg pyridoxine daily to prevent neurotoxicity.