Excreted Unchanged %
75-90
Half-Life (Normalesrd) Hours
4/5-15
Plasma Protein Binding %
10-30
Volume Of Distribution L/Kg
1.6-3.2
Dose For Normal Renal Function
15-25 mg/kg q24h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q24h[A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q24-36h[A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q48h[A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 30-50, [D]
References
Lee CS, Marbury TC, Benet LZ. Clearance calculations in hemodialysis: application to blood, plasma, and dialysate measurements for ethambutol. J Pharmacokinet Biopharm. 1980; 8: 69-81. [PMID: 7381692] / Varughese A, Brater DC, Benet LZ, Lee CS. Ethambutol kinetics in patients with impaired renal function. Am Rev Respir Dis. 1986; 134: 34-8. [PMID: 3729159]
Toxicity Notes
Decreases visual acuity. Alternative dose of 25 mg/kg 4-6 hr before each thrice weekly hemodialysis treatment has been suggested.