Half-Life (Normalesrd) Hours
1.5-3.3/3.3
Plasma Protein Binding %
99
Volume Of Distribution L/Kg
1.9-3.6
Dose For Normal Renal Function
200-400 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100%[D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100%[D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [D]
References
Daneshmend TK, Warnock DW, Turner A, Roberts CJ. Pharmacokinetics of ketoconazole in normal subjects. J Antimicrob Chemother. 1981; 8: 299-304. [PMID: 6271723] / Heel RC, Brogden RN, Carmine A, Morley PA, Speight TM, Avery GS. Ketoconazole: a review of its therapeutic efficacy in superficial and systemic fungal infections. Drugs. 1982; 23: 1-36. [PMID: 6276122] / Johnson RJ, Blair AD, Ahmad S. Ketoconazole kinetics in chronic peritoneal dialysis. Clin Pharmacol Ther. 1985; 37: 325-9. [PMID: 3971656]