Itraconazole

Excreted Unchanged %
35
Half-Life (Normalesrd) Hours
21/25
Plasma Protein Binding %
99
Volume Of Distribution L/Kg
10
Dose For Normal Renal Function
100-200 mg q12h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% (IV contraindicated) [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 100 mg q12-24h (oral only)
Supplement For Dialysis [Recommendation Level]: Pd
PD: 100 mg q12-24h (oral only)
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [B]
References
Boelaert J, Schurgers M, Matthys E, Daneels R, van Peer A, De Beule K, et al. Itraconazole pharmacokinetics in patients with renal dysfunction. Antimicrob Agents Chemother. 1988; 32: 1595-7. [PMID: 2847635] / Coronel B, Persat F, Dorez D, Moskovtchenko JF, Peins MA, Mercatello A. Itraconazole concentrations during continuous haemodiafiltration [Letter]. J Antimicrob Chemother. 1994; 34: 448-9. [PMID: 7829423] / Hardin TC, Graybill JR, Fetchick R, Woestenborghs R, Rinaldi MG, Kuhn JG. Pharmacokinetics of itraconazole following oral administration to normal volunteers. Antimicrob Agents Chemother. 1988; 32: 1310-3. [PMID: 2848442] / Heykants J, Van Peer A, Van de Velde V, Van Rooy P, Meuldermans W, Lavrijsen K, et al. The clinical pharmacokinetics of itraconazole: an overview. Mycoses. 1989; 32 Suppl 1: 67-87. [PMID: 2561187]
Toxicity Notes
Injection formulation contraindicated in CrCl <30 mL/min. For IV, normal dosing is 200 mg q12h for 4 doses, then 200 mg daily.