Half-Life (Normalesrd) Hours
3-6/75-200
Plasma Protein Binding %
<10
Volume Of Distribution L/Kg
0.6
Dose For Normal Renal Function
37.5 mg/kg q6h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q12h [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q12h-24h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q24h-48h [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 0.5-1 g/d
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [B]
References
Cutler RE, Blair AD, Kelly MR. Flucytosine kinetics in subjects with normal and impaired renal function. Clin Pharmacol Ther. 1978; 24: 333-42. [PMID: 688726] / Lau AH, Kronfol NO. Elimination of flucytosine by continuous hemofiltration. Am J Nephrol. 1995; 15: 327-31. [PMID: 7573192] / Thomson AH, Shankland G, Clareburt C, Binning S. Flucytosine dose requirements in a patient receiving continuous veno-venous haemofiltration [Letter]. Intensive Care Med. 2002; 28: 999. [PMID: 12349825]
Toxicity Notes
Hepatic dysfunction. Marrow suppression more common in azotemic patients.