Half-Life (Normalesrd) Hours
22/No data
Plasma Protein Binding %
12
Volume Of Distribution L/Kg
0.7
Dose For Normal Renal Function
100-400 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50%[A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50%[A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 100% after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 200-400 mg q24h, [A]
References
Berl T, Wilner KD, Gardner M, Hansen RA, Farmer B, Baris BA, et al. Phar-macokinetics of fluconazole in renal failure. J Am Soc Nephrol. 1995; 6: 242-7. [PMID: 7579091] / Kishino S, Koshinami Y, Hosoi T, Suda N, Takekuma Y, Gandoh S, et al. Effective fluconazole therapy for liver transplant recipients during continuous hemodiafiltration. Ther Drug Monit. 2001; 23: 4-8. [PMID: 11206042] / Muhl E, Martens T, Iven H, Rob P, Bruch HP. Influence of continuous veno-venous haemodiafiltration and continuous veno-venous haemofiltration on the pharmacokinetics of fluconazole. Eur J Clin Pharmacol. 2000; 56: 671-8. [PMID: 11214774] / Pittrow L, Penk A. Dosage adjustment of fluconazole during continuous renal replacement therapy (CAVH, CVVH, CAVHD, CVVHD). Mycoses. 1999; 42: 17-9.[PMID: 10394842] / Thomas MG, Ellis-Pegler RB. Fluconazole treatment of Candida glabrata peritonitis [Letter]. J Antimicrob Chemother. 1989; 24: 94-6. [PMID: 2550416] / Valtonen M, Tiula E, Neuvonen PJ. Effect of continuous venovenous haemofiltration and haemodiafiltration on the elimination of fluconazole in patients with acute renal failure. J Antimicrob Chemother. 1997; 40: 695-700. [PMID: 9421318]
Toxicity Notes
Doses up to 1200 mg/day have been reported.