Half-Life (Normalesrd) Hours
9-11/No data
Plasma Protein Binding %
97
Volume Of Distribution L/Kg
9-10
Dose For Normal Renal Function
70 mg initial dose, then 50 mg q24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
No change [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
No change [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
No change [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No adjustment necessary, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: No adjustment necessary, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100% dose, [D]
References
Stone JA, Holland SD, Wickersham PJ, Sterrett A, Schwartz M, Bonfiglio C, et al. Single- and multiple-dose pharmacokinetics of caspofungin in healthy men. Antimicrob Agents Chemother. 2002; 46: 739-45. [PMID: 11850256]
Toxicity Notes
Not removed with HD.