Excreted Unchanged %
48-60
Half-Life (Normalesrd) Hours
6-10/57-108
Plasma Protein Binding %
55-90
Volume Of Distribution L/Kg
>0.7
Dose For Normal Renal Function
250-500 mg bid-qid
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q8-12h [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q12-24h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q24h[D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable