General Toxicity Notes
Most agents in this group are malabsorbed in the presence of compounds that contain metals such as magnesium, calcium, aluminum, and iron. Poorly absorbed with antacids, sucralfate, and phosphate binders.
Excreted Unchanged %
High
Half-Life (Normalesrd) Hours
6/21
Plasma Protein Binding %
90
Volume Of Distribution L/Kg
0.25-0.35
Dose For Normal Renal Function
1.0 g q6h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
Avoid [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Avoid
Supplement For Dialysis [Recommendation Level]: Pd
PD: Avoid
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Dash H, Mills J. Letter: Severe metabolic acidosis associated with nalidixic acid overdose. Ann Intern Med. 1976; 84: 570-1. [PMID: 1275361] / Eliopoulos GM. New quinolones: pharmacology, pharmacokinetics, and dosing in patients with renal insufficiency. Rev Infect Dis. 1988; 10 Suppl 1: S102-5. [PMID: 3279486] / Ferry N, Cuisinaud G, Pozet N, Zech PY, Sassard J. Nalidixic acid kinetics after single and repeated oral doses. Clin Pharmacol Ther. 1981; 29: 695-8. [PMID: 7214799] / Fillastre JP, Leroy A, Moulin B, Dhib M, Borsa-Lebas F, Humbert G. Pharmaco-kinetics of quinolones in renal insufficiency. J Antimicrob Chemother. 1990; 26 Suppl B: 51-60. [PMID: 2124213] / Wolfson JS, Hooper DC. Pharmacokinetics of quinolones: newer aspects. Eur J Clin Microbiol Infect Dis. 1991; 10: 267-74. [PMID: 1864287]