General Toxicity Notes
Most agents in this group are malabsorbed in the presence of compounds that contain metals such as magnesium, calcium, aluminum, and iron. Poorly absorbed with antacids, sucralfate, and phosphate binders.
Half-Life (Normalesrd) Hours
8/44
Plasma Protein Binding %
15
Volume Of Distribution L/Kg
1.8-3.1
Dose For Normal Renal Function
400 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
200-400 mg q24h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
200 mg q24h [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for 30-50, [D]
References
Blum RA, Schultz RW, Schentag JJ. Pharmacokinetics of lomefloxacin in renally compromised patients. Antimicrob Agents Chemother. 1990; 34: 2364-8. [PMID: 2088191] / Eliopoulos GM. New quinolones: pharmacology, pharmacokinetics, and dosing in patients with renal insufficiency. Rev Infect Dis. 1988; 10 Suppl 1: S102-5. [PMID: 3279486] / Fillastre JP, Leroy A, Moulin B, Dhib M, Borsa-Lebas F, Humbert G. Pharmaco-kinetics of quinolones in renal insufficiency. J Antimicrob Chemother. 1990; 26 Suppl B: 51-60. [PMID: 2124213] / Leroy A, Fillastre JP, Humbert G. Lomefloxacin pharmacokinetics in subjects with normal and impaired renal function. Antimicrob Agents Chemother. 1990; 34: 17-20. [PMID: 2327756] / Wolfson JS, Hooper DC. Pharmacokinetics of quinolones: newer aspects. Eur J Clin Microbiol Infect Dis. 1991; 10: 267-74. [PMID: 1864287]