General Toxicity Notes
Most agents in this group are malabsorbed in the presence of compounds that contain metals such as magnesium, calcium, aluminum, and iron. Poorly absorbed with antacids, sucralfate, and phosphate binders.
Excreted Unchanged %
36±9.3
Half-Life (Normalesrd) Hours
4-12
Plasma Protein Binding %
60-70
Dose For Normal Renal Function
320 mg q24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
320 mg q24h [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
160 -320 mg q24h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
160 mg q24h [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for 30-50, [D]