Gatifloxacin

General Toxicity Notes
Most agents in this group are malabsorbed in the presence of compounds that contain metals such as magnesium, calcium, aluminum, and iron. Poorly absorbed with antacids, sucralfate, and phosphate binders.
Excreted Unchanged %
70-95
Half-Life (Normalesrd) Hours
7-14/11-40
Plasma Protein Binding %
20
Volume Of Distribution L/Kg
0.6
Dose For Normal Renal Function
400 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
400 mg initially, then 200 mg q24h [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
400 mg initially, then 200 mg q24h [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for GFR <10, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [B]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for 30-50, [D]
References
Mignot A, Guillaume M, Brault M, Gualano V, Mill&#233; rioux L, G&#246; hler K, et al. Multiple-dose pharmacokinetics and excretion balance of gatifloxacin, a new fluoroquinolone antibiotic, following oral administration to healthy Caucasian volunteers. Chemotherapy. 2002; 48: 116-21. [PMID: 12138326] / Stahlberg HJ, Gohler K, Leclerc V, et al. The effect of varying degrees of renal impairment on the pharmacokinetics and safety of gatifloxacin [Abstract 195]. 39th ICAAC, 26-29 September 1999.
Toxicity Notes
HD (4 hr) removed 14% of administered dose.