Half-Life (Normalesrd) Hours
1.2/11-16
Plasma Protein Binding %
45-60
Volume Of Distribution L/Kg
0.14-0.21
Dose For Normal Renal Function
3.1 g q4h
Adjustment For Renal Failure Method
D, I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
3.1 g q8-12h[A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
2 g q12h[A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for GFR <10 and 3.1 g after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 3.1 g q12h
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Parry MF, Neu HC. Pharmacokinetics of ticarcillin in patients with abnormal renal function. J Infect Dis. 1976; 133: 46-9. [PMID: 1107435]
Toxicity Notes
Sodium 5.2 mEq/g.