Half-Life (Normalesrd) Hours
0.5/1.2
Plasma Protein Binding %
85
Volume Of Distribution L/Kg
0.35
Dose For Normal Renal Function
1-2 g q4-6h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100%[D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100%[D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [B]
References
Golper TA, Marx MA. Drug dosing adjustments during continuous renal replacement therapies. Kidney Int Suppl. 1998; 66: S165-8. [PMID: 9573596] / Rudnick M, Morrison G, Walker B, Singer I. Renal failure, hemodialysis, and nafcillin kinetics. Clin Pharmacol Ther. 1976; 20: 413-23. [PMID: 975716]