Excreted Unchanged %
35-70
Half-Life (Normalesrd) Hours
0.7/1-2
Plasma Protein Binding %
95
Volume Of Distribution L/Kg
0.16
Dose For Normal Renal Function
125-250 mg q6h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100%[A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100%[A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100%[A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
McCloskey RV, Hayes CP Jr. Plasma levels of dicloxacillin in oliguric patients and the effect of hemodialysis. Antimicrobial Agents Chemother (Bethesda). 1967; 7: 770-2. [PMID: 5596220] / Nauta EH, Mattie H. Dicloxacillin and cloxacillin: pharmacokinetics in healthy and hemodialysis subjects. Clin Pharmacol Ther. 1976; 20: 98-108. [PMID: 1277730] / Williams TW Jr, Lawson SA, Brook MI, Ory EM, Morgen RO. Effect of hemodialysis on dicloxacillin concentration in plasma. Antimicrobial Agents Chemother (Bethesda). 1967; 7: 767-9. [PMID: 5596219]