Excreted Unchanged %
30-90
Half-Life (Normalesrd) Hours
0.8-1.5/7-20
Plasma Protein Binding %
20
Volume Of Distribution L/Kg
0.17-0.31
Dose For Normal Renal Function
250 mg-2 g q6h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q6h[A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q6-12h[A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q12-24h[A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 250 mg q12h
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50
References
Jusko WJ, Lewis GP, Schmitt GW. Ampicillin and hetacillin pharmacokinetics in normal and anephric subjects. Clin Pharmacol Ther. 1973; 14: 90-9. [PMID: 4345622]