Excreted Unchanged %
50-70
Half-Life (Normalesrd) Hours
0.9-2.3/5-20
Plasma Protein Binding %
15-25
Volume Of Distribution L/Kg
0.26
Dose For Normal Renal Function
250-500 mg q8h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q8h [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q8-12h[A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q24h[A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 250 mg q12h
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Adam D, de Visser I, Koeppe P. Pharmacokinetics of amoxicillin and clavulanic acid administered alone and in combination. Antimicrob Agents Chemother. 1982; 22: 353-7. [PMID: 7137979] / Davies BE, Boon R, Horton R, Reubi FC, Descoeudres CE. Pharmacokinetics of amoxycillin and clavulanic acid in haemodialysis patients following intravenous administration of Augmentin. Br J Clin Pharmacol. 1988; 26: 385-90. [PMID: 3190988] / Francke EL, Appel GB, Neu HC. Kinetics of intravenous amoxicillin in patients on long-term dialysis. Clin Pharmacol Ther. 1979; 26: 31-5. [PMID: 445959] / Horber FF, Frey FJ, Descoeudres C, Murray AT, Reubi FC. Differential effect of impaired renal function on the kinetics of clavulanic acid and amoxicillin. Antimicrob Agents Chemother. 1986; 29: 614-9. [PMID: 3707111] / Humbert G, Spyker DA, Fillastre JP, Leroy A. Pharmacokinetics of amoxicillin: Dosage nomogram for patients with impaired renal function. Antimicrob Agents Chemother. 1979; 15: 28-33. [PMID: 426503] / Zarowny D, Ogilvie R, Tamblyn D, MacLeod C, Ruedy J. Pharmacokinetics of amoxicillin. Clin Pharmacol Ther. 1974; 16: 1045-51. [PMID: 4433471]
Toxicity Notes
Alternative dosing schedule of 875 mg q12h in normal renal function. Should not be used for CrCl <30 mL/min.