Excreted Unchanged %
60-80%
Half-Life (Normalesrd) Hours
9-13/20-49
Plasma Protein Binding %
30-70
Volume Of Distribution L/Kg
1.0-2.2
Dose For Normal Renal Function
100 mg q12h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q12h[D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q12h >30 mL/min, q18h for 10-30 mL/min[D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q24h[D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 2.5-5 mg/kg q12h for mild/moderate infections, 10 mg/kg q12h for severe infection, [D]
Toxicity Notes
Can cause hyperkalemia and elevate serum creatinine (inhibits tubular secretion of creatinine). HD removes 20-59% of dose.