Half-Life (Normalesrd) Hours
3-7/6-12
Plasma Protein Binding %
85
Volume Of Distribution L/Kg
0.14-0.28
Dose For Normal Renal Function
1-2 g q6h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q6h[D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q8-12h[D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q12-24h[D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 2 g after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 3 g/d
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
Toxicity Notes
Protein binding decreased in ESRD. Use normal dosing for urinary tract infection in ESRD.