Excreted Unchanged %
30-40
Half-Life (Normalesrd) Hours
0.5/1
Plasma Protein Binding %
20-60
Volume Of Distribution L/Kg
0.3-0.7
Dose For Normal Renal Function
50-100 mg q6h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
Avoid <60 [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
Avoid [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicable
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Avoid
References
Conklin JD. The pharmacokinetics of nitrofurantoin and its related bioavailability. Antibiot Chemother. 1978; 25: 233-52. [PMID: 352255]