Linezolid

Excreted Unchanged %
30
Half-Life (Normalesrd) Hours
4.7-6.4/6.1-8.4
Plasma Protein Binding %
30
Volume Of Distribution L/Kg
0.63
Dose For Normal Renal Function
600 mg q12h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No dose adjustment, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: No dose adjustment, [B]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 600 mg q12h, [A]
References
Brier ME, Stalker DJ, Aronoff GR, Batts DH, Ryan KK, O&#146; Grady M, et al. Pharmacokinetics of linezolid in subjects with renal dysfunction. Antimicrob Agents Chemother. 2003; 47: 2775-80. [PMID: 12936973] / Fiaccadori E, Maggiore U, Rotelli C, Giacosa R, Parenti E, Picetti E, et al. Removal of linezolid by conventional intermittent hemodialysis, sustained low-efficiency dialysis, or continuous venovenous hemofiltration in patients with acute renal failure. Crit Care Med. 2004; 32: 2437-42. [PMID: 15599148] / Kraft MD, Pasko DA, DePestel DD, Ellis JJ, Peloquin CA, Mueller BA. Linezolid clearance during continuous venovenous hemodiafiltration: a case report. Pharmaco-therapy. 2003; 23: 1071-5. [PMID: 12921253] / Meyer B, Kornek GV, Nikfardjam M, Karth GD, Heinz G, Locker GJ, et al. Multiple-dose pharmacokinetics of linezolid during continuous venovenous haemofiltration. J Antimicrob Chemother. 2005; 56: 172-9. [PMID: 15905303] / Pea F, Viale P, Lugano M, Pavan F, Scudeller L, Della Rocca G, et al. Linezolid disposition after standard dosages in critically ill patients undergoing continuous venovenous hemofiltration: a report of 2 cases. Am J Kidney Dis. 2004; 44: 1097-102. [PMID: 15558532]
Toxicity Notes
Metabolites may accumulate in patients with renal failure; significance unknown. Approximately 30% of dose is removed by HD (3 hr).