Lincomycin

Excreted Unchanged %
10-15
Half-Life (Normalesrd) Hours
4-5/10-20
Plasma Protein Binding %
70-80
Volume Of Distribution L/Kg
0.31-0.6
Dose For Normal Renal Function
0.5 g q6h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q6h[D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q6-12h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q12-24h [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Golper TA, Gleason JR, Vincent HH, et al. Drug removal during high efficiency and high flux hemodialysis. Contemp Iss Nephrol. 1993; 27: 175-208. [PMID unavailable] / Keane WF, Everett ED, Golper TA, Gokal R, Halstenson C, Kawaguchi Y, et al. Peritoneal dialysis-related peritonitis treatment recommendations. 1993 update. The Ad Hoc Advisory Committee on Peritonitis Management. International Society for Peritoneal Dialysis. Perit Dial Int. 1993; 13: 14-28. [PMID: 8443273] / Malacoff RF, Finkelstein FO, Andriole VT. Effect of peritoneal dialysis on serum levels of tobramycin and clindamycin. Antimicrob Agents Chemother. 1975; 8: 574-80. [PMID: 1211913] / St Peter WL, Redic-Kill KA, Halstenson CE. Clinical pharmacokinetics of antibiotics in patients with impaired renal function. Clin Pharmacokinet. 1992; 22: 169-210. [PMID: 1559311]