Half-Life (Normalesrd) Hours
4/No data
Plasma Protein Binding %
85-95
Volume Of Distribution L/Kg
0.1
Dose For Normal Renal Function
1 g q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% (see notes) [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50%[D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: See notes, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, no adjustment needed unless <30 mL/min, [B]
References
Holland SD, Majumdar A, Musson D, et al. Pharmacokinetics of ertapenem in renal insufficiency. Clin Pharmacol Ther. 2001; 69: 16. [PMID unavailable]
Toxicity Notes
Manufacturer recommends 50% reduced dose to 500 mg daily for CrCl ≤ 30 mL/min. A supplemental dose of 150 mg after hemodialysis is recommended if daily dose given less than 6 hr before start of hemodialysis.