Half-Life (Normalesrd) Hours
8.1
Plasma Protein Binding %
92
Volume Of Distribution L/Kg
0.09
Dose For Normal Renal Function
4 mg/kg q24h
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% q24-48h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% q48h [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 8 mg/kg q48h, [C]
References
Huang V, Rybak MJ. Evaluation of daptomycin activity against Staphylococcus aureus in an in vitro pharmacodynamic model under normal and simulated impaired renal function. J Antimicrob Chemother. 2006; 57: 116-21. [PMID: 16311369]