Excreted Unchanged %
5-20
Half-Life (Normalesrd) Hours
20-30/No data
Plasma Protein Binding %
70-90
Volume Of Distribution L/Kg
1.0-1.5
Dose For Normal Renal Function
50-100 mg q24h (for malariaprohylaxis once weekly)
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
No data/ 100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
No data [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
No data [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data: Dose for GFR <10
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Edstein MD, Rieckmann KH, Veenendaal JR. Multiple-dose pharmacokinetics and in vitro antimalarial activity of dapsone plus pyrimethamine (Maloprim) in man. Br J Clin Pharmacol. 1990; 30: 259-65. [PMID: 2206787] / Zuidema J, Hilbers-Modderman ES, Merkus FW. Clinical pharmacokinetics of dapsone. Clin Pharmacokinet. 1986; 11: 299-315. [PMID: 3530584]
Toxicity Notes
Hemolytic anemia with G6PD deficiency.